DnaA is a protein present in prokaryotes that promotes DNA denaturation in the oriC site during replication. The formation of the oriC / DnaA complex and the denaturation of DNA require ATP hydrolysis. The origin of Escherichia coli replication, known as oriC, consists of repetitions of a sequence of thirteen nucleotides followed by repetitions of a sequence of nine. DnaA is a protein that is responsible for the recognition and binding of repetitions by nine, a binding that induces DNA winding around the protein itself to form a protein core. This wrap favors accessibility to the rich AT region (present in thirteen repetitions), thus enabling enzymes and other factors to bind and start replication.
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