After the descent of Charles VIII, king of France, in Italy and death in 1498 because of an accident, his successor Louis XII decided to go to the peninsula to take control of Milan, as he did in 1500; , who was potentially threatened by the Aragonese presence in southern Italy, taking advantage of the reign of the regent to a collateral dynasty, made a secret pact with Ferdinand II of Aragon, king of Spain, with Isabella of Castile. The treaty, signed on 11 November 1500, provided for the return, by the French king, of the Kingdom of Naples to the main branch of the Aragonian dynasty. The regent of Naples, however, who in the year 1500 was Frederick III (counting from Frederick II of Swabia, who died in 1250), decided to abdicate in favor of Louis XII, thus triggering a conflict between two European powers, whose armies clashed on Italian soil (Italian War of 1499-1504), until 1504 (Armistice of Lyon).
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