Iso-enzymes


Iso-enzymes are enzymes that have a different amino acid sequence than regular enzymes, but have the same biochemical function. These enzymes usually differ from kinetic parameters (i.e., KM values ​​or VMax), or different regulatory properties. An isoenzyme is usually caused by a mutation in the original gene. An example of an isoenzyme is lactic dehydrogenase (LDH), which is a tetramer consisting of a combination of two different monomers. Another example of an isoenzyme is glucokinase, a variant of hexokinase not inhibited by glucose-6-phosphate.

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